Research

One cell divides into two cells.

 There are still many questions about cell division to be answered that are not as simple as it might seem at first sight. It is important to understand how cells know when to divide and when to stop in terms of our health and longevity. Uncontrolled cell division is a major characteristic of cancer cells, whereas controlled cell division is essential for stem cell maintenance. We are trying to understand how cell division is controlled. We do our research for better understanding of the fundamental operating principle of life. 

 We are especially interested in how protein phosphorylation is regulated by a balance between protein kinase and phosphatase. Because the cell division cycle is driven by protein phosphorylation. Compared with kinases, phosphatases are still full of unknowns. We recently found new mechanism by which CDK (cyclin dependent kinase) and one particular type of PP2A (type-IIA phosphatase) are communicating each other, just like a seesaw game! Are other phosphatases playing it as well? Or is there any other equipment in the playground?

 
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